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Merck
CN

SML0542

Sigma-Aldrich

SR 27417

≥98% (HPLC)

Synonym(s):

Faropafant, N,N-Dimethyl-N′-(3-pyridinylmethyl)-N′-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine, N1,N1-Dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine

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About This Item

Empirical Formula (Hill Notation):
C28H40N4S
CAS Number:
136468-36-5
Molecular Weight:
464.71
MDL number:
MFCD00904759
UNSPSC Code:
12352200
PubChem Substance ID:
329825543
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc3cccnc3)c(c1)C(C)C

InChI

1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3

InChI key

VVBFISAUNSXQGZ-UHFFFAOYSA-N

Biochem/physiol Actions

SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist.
SR 27417 is a selective, highly potent, competitive platelet-activating factor (PAF) receptor antagonist.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000320229
0000320229
0000144865
0000144865

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Céline Cheminade et al.
Biology of reproduction, 66(2), 421-428 (2002-01-24)
1-O-alkylglycerols are naturally occurring ether lipids with potent biological activities. They may interfere with lipidic signaling, and they amplify platelet-activating factor (PAF) biosynthesis in a monocyte cell line. The PAF is produced by mammalian sperm and is an important activator
Iradj Sobhani et al.
American journal of physiology. Gastrointestinal and liver physiology, 282(4), G727-G734 (2002-03-19)
Helicobacter pylori may increase or inhibit gastric acid. We studied acid variations and plasma gastrin in cats harboring Helicobacter felis, harboring H. pylori, or free of gastric pathogens with reference to thioperamide (H(3) receptor antagonist) and SR-27417A (PAF receptor antagonist).
F P Gómez et al.
The European respiratory journal, 11(4), 835-839 (1998-06-12)
Inhaled platelet-activating factor (PAF), both in normals and in asthmatic patients, provokes transient systemic effects, neutropenia, bronchoconstriction and arterial oxygenation abnormalities similar to those shown in spontaneous exacerbations of asthma. To investigate the efficacy of a new PAF-receptor antagonist, SR
P R Tiller et al.
Journal of chromatography. A, 771(1-2), 119-125 (1997-05-30)
The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize
P Seth et al.
Thrombosis research, 76(6), 503-512 (1994-12-15)
Effect of three specific PAF antagonists, SR-27417, BN-50739 and ginkgolide derivative BN-52021 have been evaluated in models of thrombosis in the mouse, rat and cat. Thrombosis in the mouse was induced by intravenous infusion of collagen and adrenaline. In rats
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