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Merck
CN

SML0581

Sigma-Aldrich

SR 58894A

≥98% (HPLC)

Synonym(s):

3-(2-Allylphenoxy)-1-[(1S)-1,2,3,4-tetrahydro-naphth-1-ylamino]-(2 S)-2-propanol hydrochloride, SR58894A

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About This Item

Empirical Formula (Hill Notation):
C22H27NO2 · HCl
CAS Number:
132017-03-9
Molecular Weight:
373.92
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -19 to -25°, c = 1 in methanol

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Potent, selective antagonist of β-adrenergic receptor.
SR58894A is a potent and selective antagonist of β3-adrenergic receptor.
SR 58894A is also known as (3-(2-allylphenoxy)-1-[(1 S)-1,2,3,4-tetrahydronaphth-1-ylamino]-(2 S)-2-propanol hydrochloride, Kissei). It has the ability to antagonize relaxation, stimulated by isoprenaline.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122M4617V

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Pharmacological characterization of beta-adrenoceptor subtypes mediating relaxation in porcine isolated ureteral smooth muscle
Wanajo I et al.
The Journal of Urology, 172(3), 1155-1159 (2004)

Articles

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

β-肾上腺素能受体

β-肾上腺素受体可被去甲肾上腺素或肾上腺素激活。详细了解β-肾上腺素受体在蛋白质表达、细胞信号传导和代谢研究中的作用。

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