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SML0593

CGP52432

≥98% (HPLC)

Synonym(s):

[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid

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About This Item

Empirical Formula (Hill Notation):
C15H24Cl2NO4P
CAS Number:
139667-74-6
Molecular Weight:
384.24
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[P](=O)(O)(C(OCC)OCC)CCCNCc1cc(c(cc1)Cl)Cl

InChI

1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChI key

GJZVQXWEIYRHBE-UHFFFAOYSA-N

Application

CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
  • to study its effects on the simulation of the onset of status epilepticus (SE) in mice
  • for voltage-clamp recording in mice neurons
  • to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus

Biochem/physiol Actions

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.
CGP52432 is a very potent antagonist of GABAB receptors.
CGP52432 is a very potent antagonist of GABAB receptors. (IC50 = 85 nM).

Features and Benefits

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Do not freeze.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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