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Merck
CN

SML0598

Sigma-Aldrich

SDZ 220-581 hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H17ClNO5P · HCl
CAS Number:
179411-93-9
Molecular Weight:
406.20
MDL number:
MFCD28124389
UNSPSC Code:
12352202
PubChem Substance ID:
329825568
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -5 to -8°, c = 1 in 1 M HCl

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

OC([C@@H](N)CC1=CC(C2=CC=CC=C2Cl)=CC(CP(O)(O)=O)=C1)=O.Cl

InChI

1S/C16H17ClNO5P.ClH/c17-14-4-2-1-3-13(14)12-6-10(8-15(18)16(19)20)5-11(7-12)9-24(21,22)23;/h1-7,15H,8-9,18H2,(H,19,20)(H2,21,22,23);1H/t15-;/m0./s1

InChI key

WSYIMHDAUSNYSF-RSAXXLAASA-N

Biochem/physiol Actions

SDZ 220-581 is a competitive NMDA receptor antagonist
SDZ 220-581 is a competitive NMDA receptor antagonist that penetrates the blood brain barrier. ISDZ 220-581 selectively blocks the glutamate recognition-site of the NMDA receptor and reduces prepulse inhibition (PPI). SDZ 220-581 reduces prepulse inhibition (PPI) and has an ED50 of less than 3.2 mg/kg for protection against MES-induced seizures.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
034M4717V

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