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Merck
CN

SML0600

LPSF/GQ-02

≥98% (HPLC)

Synonym(s):

(5Z)-5-[(4-Chlorophenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione, 5-(4-Chloro-benzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione, GQ-02

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About This Item

Empirical Formula (Hill Notation):
C18H14ClNO2S
CAS Number:
870554-60-2
Molecular Weight:
343.83
NACRES:
NA.77
UNSPSC Code:
12352202

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

LPSF/GQ-02 is a new thiazolidinedione that shows improved insulin resistance, reduces the area of atherosclerotic lesions, and offers a protective effect for the endothelium in LDL receptor-deficient mice.
LPSF/GQ-02 is a new thiazolidinedione that shows improved insulin resistance, reduces the area of atherosclerotic lesions, and offers a protective effect for the endothelium in LDL receptor-deficient mice. LPSF/GQ-02 induced an overexpression of eNOS and significantly inhibited the expression of metalloproteinases, both of which can result in anti-inflammatory effects.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H319,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
013M4614V

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Articles

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

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