SML0622
NS11021
≥98% (HPLC)
Synonym(s):
N′-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea
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About This Item
Empirical Formula (Hill Notation):
C16H9BrF6N6S
CAS Number:
Molecular Weight:
511.24
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
NS11021 is a potent, selective activator of the large conductance Ca2+-activated K+-channel, KCa1.1.
NS11021 is an activator of the large conductance Ca2+-activated K+-channel, KCa1.1.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Stephen Shrum et al.
Biomolecules, 9(12) (2019-12-11)
Kidneys from deceased donors used for transplantation are placed in cold storage (CS) solution during the search for a matched recipient. However, CS causes mitochondrial injury, which may exacerbate renal graft dysfunction. Here, we explored whether adding NS11021, an activator
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