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Merck
CN

SML0624

PE 154

≥97% (HPLC)

Synonym(s):

2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid

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About This Item

Empirical Formula (Hill Notation):
C35H35N5O4
CAS Number:
Molecular Weight:
589.68
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
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assay

≥97% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C35H35N5O4/c1-3-40(4-2)24-17-18-27-31(20-24)44-35(43)28(34(27)42)21-36-23-15-13-22(14-16-23)19-32(41)38-39-33-25-9-5-7-11-29(25)37-30-12-8-6-10-26(30)33/h5,7,9,11,13-18,20-21,36H,3-4,6,8,10,12,19H2,1-2H3,(H,37,39)(H,38,41)/b28-21+

InChI key

CYZIIGRHLSZNAV-SGWCAAJKSA-N

Biochem/physiol Actions

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to associate with β-amyloid plaques, and histological co-localization of AChE and Ab peptides is well established in Alzheimer′s disease. PE-154 is a fluorescent inhibitor of both AChE and BChE with IC50 values of 280 pM and 16 nM. PE-154 stains Aβ plaques in both rodent and human tissue samples, and does not cross react with phospho-tau.
PE 154 is a fluorescent acetylcholinesterase inhibitor.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

乙酰胆碱由胆碱乙酰转移酶从乙酰辅酶A和胆碱合成而来。用于生成乙酰胆碱的胆碱除了在肝脏中合成外,还来源于膳食。

Global Trade Item Number

SKUGTIN
SML0624-10MG04061832076232
SML0624-50MG04061832076249

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