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Merck
CN

SML0626

Sigma-Aldrich

RFRP-3 human trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

NPVF, Neuropeptide VF (124-131), RFamide-related peptide-3

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About This Item

Empirical Formula (Hill Notation):
C45H72N14O10 · xC2HF3O2
CAS Number:
311309-27-0
Molecular Weight:
969.14 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1

InChI key

JFZCLMZUABKABL-GVCDGELBSA-N

Amino Acid Sequence

Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2

Biochem/physiol Actions

RFRP-3 (RFamide-related peptide-3) is a homolog of avian gonadotropin-inhibitory hormone. RFRP-3 binds to the GPR147 receptor (also known as neuropeptide FF receptor 1). RFRP-3 blocks release of gonadotropin from the pituitary, and inhibits FSH-, LH- and forskolin-stimulated cAMP accumulation and progesterone production in human granulosa-lutein cells.
RFRP-3 is a homolog of avian gonadotropin-inhibitory hormone. RFRP-3 binds to the GPR147 receptor (also known as neuropeptide FF receptor 1).

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
033M4719V

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