SML0657
N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
≥98% (HPLC)
Synonym(s):
W 5 hydrochloride, W-5 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H22N2O2S · HCl
CAS Number:
Molecular Weight:
342.88
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(NCCCCCCN)c1c2c(ccc1)cccc2.Cl
InChI
1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChI key
HOCSVIGHWPLMFC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder or crystals
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
N-(6-Aminohexyl)-1-naphthalenesulfonamide (W-5) is a cell permeable calmodulin antagonist that binds directly to the enzyme.
N-(6-Aminohexyl)-1-naphthalenesulfonamide (W-5) is a cell permeable calmodulin antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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K Ahmad et al.
Archives of andrology, 35(3), 187-208 (1995-11-01)
The role of Ca2+, calmodulin, and protein phosphatases on motility and hyperactivation of noncapacitated, capacitating, and detergent-permeabilized reactivated human sperm was examined. In noncapacitated sperm, W7 inhibited percent motility (%MOT), curvilinear velocity (VCL), amplitude of lateral head displacement (ALH), and
C S Im et al.
The Plant cell, 8(12), 2245-2253 (1996-12-01)
The Chlamydomonas reinhardtii nuclear gene gsa, which encodes the early chlorophyll biosynthetic enzyme glutamate 1-semialdehyde aminotransferase (GSAT), is specifically induced by blue light in cells synchronized in a 12-hr-light and 12-hr-dark regime. Light induction required the presence of a nitrogen
A Takahashi et al.
Pancreas, 21(3), 231-239 (2000-10-20)
The mouse intestinal neuroendocrine tumor cell line STC-1 secretes cholecystokinin (CCK) and other hormones. We investigated the role of Ca2+, calmodulin (CaM), and protein kinase C (PKC) in the regulation of CCK release from STC-1 cells. Phorbol 12-myristate 13-acetate (TPA)
C Yang et al.
Molecular endocrinology (Baltimore, Md.), 14(2), 317-326 (2000-02-16)
It has been previously reported that calmodulin plays a regulatory role in the insulin stimulation of glucose transport. To examine the basis for this observation, we examined the effect of a panel of calmodulin antagonists that demonstrated a specific inhibition
Deirdre C Lawe et al.
Molecular biology of the cell, 14(7), 2935-2945 (2003-07-15)
Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca2+/CaM is required for early endosome fusion in vitro, however, the molecular basis for this requirement is unknown. An additional requirement for endosome fusion
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