SML0657
N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
≥98% (HPLC)
Synonym(s):
W 5 hydrochloride, W-5 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H22N2O2S · HCl
CAS Number:
Molecular Weight:
342.88
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(NCCCCCCN)c1c2c(ccc1)cccc2.Cl
InChI
1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChI key
HOCSVIGHWPLMFC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder or crystals
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
N-(6-Aminohexyl)-1-naphthalenesulfonamide (W-5) is a cell permeable calmodulin antagonist that binds directly to the enzyme.
N-(6-Aminohexyl)-1-naphthalenesulfonamide (W-5) is a cell permeable calmodulin antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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P Menè et al.
Journal of the American Society of Nephrology : JASN, 7(7), 983-990 (1996-07-01)
Sustained Ca2+ influx follows discharge of intracellularly stored Ca2+ in a variety of cell types previously equilibrated in Ca(2+)-free media, including cultured human mesangial cells. This Ca2+ influx pathway has been referred to as capacitative Ca2+ entry or Ca2+ release-activated
R M Bernal et al.
Parasitology research, 84(9), 687-693 (1998-10-10)
The protozoan Giardia lamblia initiates infection when trophozoites emerge from a cyst in the hosts by the excystation process. Although this process is crucial to the initiation of infection by G. lamblia, little is known about its regulation. To study
S Suzuki et al.
Journal of cardiovascular pharmacology, 36(5), 609-616 (2000-11-07)
Apolipoprotein (apo) A-I generates high-density lipoprotein (HDL) by removing cellular cholesterol and phospholipid on the interaction with cells as a main source of plasma HDL. The reaction is induced by dibutylyl cyclic (dbc) adenosine monophosphate (AMP) in RAW 264, mouse
T Watanabe et al.
Biochimica et biophysica acta, 1304(2), 161-169 (1996-11-22)
In a previous study, we characterized prostanoid and thrombin receptors expressed on a megakaryoblastic cell line, MEG-01s (Blood 78, 2328-2336, 1991). In this study, we examines the mechanism of cross-talk between intracellular Ca2+ ([Ca2+]i) and cAMP signalings through prostanoid and
A Ito et al.
European journal of biochemistry, 251(1-2), 353-358 (1998-03-10)
The treatment of human uterine cervical fibroblasts with concanavalin A (ConA), or a specific calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) or trifluoperazine resulted in accumulation of an active form of matrix metalloproteinase 2 (MMP-2, gelatinase A). In contrast, N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5), a weaker
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