SML0659
LYG-202
≥98% (HPLC)
Synonym(s):
5-Hydroxy-8-methoxy-7-[4-(4-methyl-1-piperazinyl)butoxy]-2-phenyl-4H-1-benzopyran-4-one
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About This Item
Empirical Formula (Hill Notation):
C25H30N2O5
CAS Number:
Molecular Weight:
438.52
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
LYG-202 is a synthetic flavanoid that induces apoptosis and is a CK2 inhibitor.
LYG-202 is a synthetic flavanoid that induces apoptosis in several cancer cell lines. LYG-202 induces G1/S phase cell cycle arrest and apoptosis in HCT116 cells by a mechanism that involves increases in p21(WAF1/Cip1) and Rb expression. In HepG2 cells, the compound LYG-202 potentiates the apoptotic effects of TNFα by inhibiting casein kinase 2 (CK2).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Faiza M Kalfalah et al.
Cell cycle (Georgetown, Tex.), 14(11), 1704-1715 (2015-04-16)
To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes
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