SML0682
PluriSIn #1
≥95% (HPLC)
Synonym(s):
Isonicotinic acid 2-phenylhydrazide; 4-Pyridinecarboxylic acid 2-phenylhydrazide, NSC 14613
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About This Item
Empirical Formula (Hill Notation):
C12H11N3O
CAS Number:
Molecular Weight:
213.24
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
InChI key
HUDWXDLBWRHCKO-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
PluriSIn #1 is a pluripotent cell specific inhibitor that induces ER stress and apoptosis in hPSC (human pluripotent stem cells). PluriSIn #1 selectively purges hPSCs while saving progenitor and differentiated cells. PluriSIn #1 is an inhibitor of stearoyl-coA desaturase (SCD1).
PluriSIn #1 is a pluripotent cell specific inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Uri Ben-David et al.
Nature protocols, 9(3), 729-740 (2014-03-01)
The tumorigenicity of human pluripotent stem cells (hPSCs) is widely acknowledged as a major obstacle that withholds their application in regenerative medicine. This protocol describes two efficient and robust ways to chemically eliminate the tumor-initiating hPSCs from monolayer culture. The
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