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SML0704

1-Methylnicotinamide chloride

Name: 1-Methylnicotinamide chloride
Brand: SIGMA

≥98% (HPLC), antithrombotic, powder

Synonym(s):

3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride

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About This Item

Empirical Formula (Hill Notation):

C₇H₉ClN₂O

CAS Number:

1005-24-9

Molecular Weight:

172.61

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

1-Methylnicotinamide chloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 15 mg/mL, clear

storage temp.

room temp

SMILES string

Cl.[n+]1(cc(ccc1)C(=N)[O-])C

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide with antithrombotic and anti-inflammatory effects.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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BMC molecular and cell biology, 21(1), 26-26 (2020-04-16)

Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the embryological gastrulation organizer that orchestrates vertebrate tissue differentiation. Here, we

Global Trade Item Number

SKU	GTIN
SML0704-10MG	04061837101342
SML0704-50MG	04061832723815

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