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Merck
CN

SML0707

FKGK11

≥98% (GC)

Synonym(s):

1,1,1,2,2-Pentafluoro-7-phenyl-3-Heptanone

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About This Item

Empirical Formula (Hill Notation):
C13H13F5O
CAS Number:
1071000-98-0
Molecular Weight:
280.23
UNSPSC Code:
41106300
NACRES:
NA.77

Key Documents

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InChI

1S/C13H13F5O/c14-12(15,13(16,17)18)11(19)9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2

InChI key

ROPVXAWEVYWEQY-UHFFFAOYSA-N

assay

≥98% (GC)

form

oil

color

colorless to yellow

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

FKGK11 is a potent inhibitor of GVIA iPLA2 with little or no inhibition against GIVA cPLA2 (XI(50) = 0.0073 and >0.91, respectively).
FKGK11 is a potent inhibitor of GVIA iPLA2 with little or no inhibition against GIVA cPLA2 (XI(50) = 0.0073 and >0.91, respectively). The compound displays a slight inhibition against GVsPLA2. FKGK11 potently inhibited the progression and severity in a murine experimental autoimmune encephalomyelitis (EAE) model.

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitive; suggest to store under nitrogen in freezer.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
053M4608V

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Articles

Phospholipase A2

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

磷脂酶A2

磷脂酶A2（PLA2）代表的是一类可水解甘油磷脂的sn-2酯以产生脂肪酸和溶血磷脂的酶。目前已知的是，其中一些酶可在哺乳动物细胞中释放花生四烯酸以用于类花生酸的生物合成，因此PLA2抑制剂的开发引起了相当大的兴趣。基于氨基酸序列，现有超过12种不同的哺乳动物PLA2以及多种非哺乳动物的形式，它们被归类为具有多个亚组的14个组别。

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