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SML0713

2′-C-Methylguanosine

≥98% (HPLC)

Synonym(s):

2′-C-Methyl-guanosine, 2-C′-MeG

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About This Item

Empirical Formula (Hill Notation):
C11H15N5O5
CAS Number:
374750-30-8
Molecular Weight:
297.27
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

−20°C

InChI

1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1

InChI key

NVKAMPJSWMHVDK-GITKWUPZSA-N

Application

2′-C-Methylguanosine has been used as reference inhibitor to study cytotoxicity.

Biochem/physiol Actions

2′-C-methylguanosine is also known as BMS-986094. This prodrug is used for the treatment of chronic hepatitis C virus infection.
2′-C-Methylguanosine (2′-MeG) is a potent and specific RNA dependent RNA polymerase NS5B inhibitor of the hepatitis C virus (HCV).
2′-C-Methylguanosine (2′-MeG) is a potent and specific RNA dependent RNA polymerase NS5B inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
063M4723V

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In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2?-C-Methylguanosine Prodrug BMS-986094: Potential Role in Clinical Cardiovascular Toxicity
Li W, et al.
International Journal of Toxicology, 36(1), 35-49 (2017)
Activity of bis (7-hydroxycoumarin) Mannich bases against bovine viral diarrhoea virus
Ibrahim, et al.
Antiviral Research, 134, 153-160 (2016)

Global Trade Item Number

SKUGTIN
SML0713-25MG04061832634456
SML0713-5MG04061832634463

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