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Merck
CN

SML0721

LSN2463359

≥98% (HPLC)

Synonym(s):

N-(1-Methylethyl)-5-(pridin-4-ylethynyl)pyridine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C16H15N3O
CAS Number:
1401031-52-4
Molecular Weight:
265.31
UNSPSC Code:
12352202
NACRES:
NA.77

Key Documents

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InChI

1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20)

InChI key

STAFRSGTRKNXHF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

LSN2463359 is a selactive brain penetrant mGluR5 positive allosteric modulator.
LSN2463359 is a selactive brain penetrant mGluR5 positive allosteric modulator. LSN2463359 is a potentiator of mGluR5-mediated Ca2+ influx in vitro, giving curve shifts 2 to 3 fold over agonist alone. In vivo, the compound exerts wake-promoting, cognitive and motor effects.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
053M4741V

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Articles

Glutamate Receptors (G Protein Family)

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