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Merck
CN

SML0722

Sigma-Aldrich

CU-CPT22

≥98% (HPLC)

Synonym(s):

5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H22O7
CAS Number:
1416324-85-0
Molecular Weight:
362.37
MDL number:
MFCD26406409
UNSPSC Code:
12352200
PubChem Substance ID:
329825591

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

orange to dark red

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(O)C(OC)=CC2=C1C(C(O)=CC(C(OCCCCCC)=O)=C2)=O

InChI

1S/C19H22O7/c1-3-4-5-6-7-26-19(24)12-8-11-10-14(25-2)17(22)18(23)15(11)16(21)13(20)9-12/h8-10,22-23H,3-7H2,1-2H3,(H,20,21)

InChI key

UBQFTTUFRSSOHE-UHFFFAOYSA-N

Biochem/physiol Actions

CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2.
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H334,H410

Precautionary Statements

P261 - P273 - P342 + P311 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Resp. Sens. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
114M4614V
063M4603V

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Joo Youn Lee et al.
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Rafael M Rezende et al.
Nature communications, 9(1), 3151-3151 (2018-08-10)
γδ T cells have many known functions, including the regulation of antibody responses. However, how γδ T cells control humoral immunity remains elusive. Here we show that complete Freund's adjuvant (CFA), but not alum, immunization induces a subpopulation of CXCR5-expressing
Stephanie Bock et al.
Pharmacological research, 105, 44-53 (2016-01-23)
Langerhans cells (LCs) represent a highly specialized subset of epidermal dendritic cells (DCs), yet not fully understood in their function of balancing skin immunity. Here, we investigated in vitro generated Langerhans-like cells obtained from the human acute myeloid leukaemia cell
Yuming Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(2), 827-837 (2018-07-23)
Dairy cows with clinical ketosis display a negative energy balance and high blood concentrations of non-esterified fatty acids (NEFAs), the latter of which is an important pathological factor of ketosis in cows. The aims of this study were to investigate
Jieun Kim et al.
Nutrients, 10(7) (2018-07-07)
Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether
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