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SML0734

Sigma-Aldrich

MitoPY1

≥95% (HPLC), 1:1 iodide complex

Synonym(s):

[4-[4-[3-Oxo-6′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3′-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide

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About This Item

Empirical Formula (Hill Notation):
C52H53BN2O5P · I
CAS Number:
1041634-69-8
Molecular Weight:
954.68
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Application

MitoPY1 has been used as a specific mitochondrial H2O2 probe to measure mitochondrial ROS (reactive oxygen species) level.

Biochem/physiol Actions

MiroPY1 is a cell-permeable fluorescent sensor that is highly selective for detecting the presence of H2O2 within the mitochondria of living cells.
MiroPY1 is a fluorescent H2O2 sensor.
MiroPY1 is an irreversible and bifunctional dye. It employs a triphenylphosphonium targeting group and a boronate-based molecular switch to specifically respond to H2O2 over competing reactive oxygen species (ROS) in the mitochondria. It does not require transfection. MiroPY1 is photostable and limits false positives.

Other Notes

Light sensitive
Molecule is a 1:1 iodide complex.

Legal Information

This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
063M4613V

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Christian Sávio-Silva et al.
International journal of molecular sciences, 22(4) (2021-02-10)
Diabetic kidney disease (DKD) is a worldwide microvascular complication of type 2 diabetes mellitus (T2DM). From several pathological mechanisms involved in T2DM-DKD, we focused on mitochondria damage induced by hyperglycemia-driven reactive species oxygen (ROS) accumulation and verified whether mesenchymal stem
NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting ?stemness?.
Bonuccelli G, et al.
Oncotarget, 8(13), 20667-20667 (2017)
(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression.
Rastogi N, et al.
Free Radical Biology & Medicine, 68, 288-301 (2014)
Glutamate dehydrogenase (GDH) regulates bioenergetics and redox homeostasis in human glioma.
Zhang J, et al.
Oncotarget, 295(10), 799-800 (2016)
Bryan C Dickinson et al.
Nature protocols, 8(6), 1249-1259 (2013-06-01)
Mitochondria peroxy yellow 1 (MitoPY1) is a small-molecule fluorescent probe that selectively tracks to the mitochondria of live biological specimens and responds to local fluxes of hydrogen peroxide (H(2)O(2)) by a turn-on fluorescence enhancement. This bifunctional dye uses a triphenylphosphonium
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