SML0734
MitoPY1
≥95% (HPLC), 1:1 iodide complex
Synonym(s):
[4-[4-[3-Oxo-6′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3′-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide
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About This Item
Empirical Formula (Hill Notation):
C52H53BN2O5P · I
CAS Number:
Molecular Weight:
954.68
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
storage condition
protect from light
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Application
MitoPY1 has been used as a specific mitochondrial H2O2 probe to measure mitochondrial ROS (reactive oxygen species) level.
Biochem/physiol Actions
MiroPY1 is a cell-permeable fluorescent sensor that is highly selective for detecting the presence of H2O2 within the mitochondria of living cells.
MiroPY1 is a fluorescent H2O2 sensor.
MiroPY1 is an irreversible and bifunctional dye. It employs a triphenylphosphonium targeting group and a boronate-based molecular switch to specifically respond to H2O2 over competing reactive oxygen species (ROS) in the mitochondria. It does not require transfection. MiroPY1 is photostable and limits false positives.
Other Notes
Light sensitive
Molecule is a 1:1 iodide complex.
Legal Information
This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Christian Sávio-Silva et al.
International journal of molecular sciences, 22(4) (2021-02-10)
Diabetic kidney disease (DKD) is a worldwide microvascular complication of type 2 diabetes mellitus (T2DM). From several pathological mechanisms involved in T2DM-DKD, we focused on mitochondria damage induced by hyperglycemia-driven reactive species oxygen (ROS) accumulation and verified whether mesenchymal stem
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Bonuccelli G, et al.
Oncotarget, 8(13), 20667-20667 (2017)
(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression.
Rastogi N, et al.
Free Radical Biology & Medicine, 68, 288-301 (2014)
Glutamate dehydrogenase (GDH) regulates bioenergetics and redox homeostasis in human glioma.
Zhang J, et al.
Oncotarget, 295(10), 799-800 (2016)
Bryan C Dickinson et al.
Nature protocols, 8(6), 1249-1259 (2013-06-01)
Mitochondria peroxy yellow 1 (MitoPY1) is a small-molecule fluorescent probe that selectively tracks to the mitochondria of live biological specimens and responds to local fluxes of hydrogen peroxide (H(2)O(2)) by a turn-on fluorescence enhancement. This bifunctional dye uses a triphenylphosphonium
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