SML0781
NSC109555
≥98% (HPLC)
Synonym(s):
2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
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About This Item
Empirical Formula (Hill Notation):
C19H24N10O · 2CH3SO3H
CAS Number:
Molecular Weight:
600.67
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
InChI
1S/C19H24N10O.2CH4O3S/c1-11(26-28-17(20)21)13-3-7-15(8-4-13)24-19(30)25-16-9-5-14(6-10-16)12(2)27-29-18(22)23;2*1-5(2,3)4/h3-10H,1-2H3,(H4,20,21,28)(H4,22,23,29)(H2,24,25,30);2*1H3,(H,2,3,4)/b26-11+,27-12+;;
InChI key
HXDBGZUARNKHBV-XMDRLFCYSA-N
Biochem/physiol Actions
NSC109555 is a selective ChK2 inhibitor.
NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.
Features and Benefits
This compound is featured on the Csk page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
The C-terminal c-Src kinase (Csk) is a 50-kDa cytosolic tyrosine kinase expressed in all examined cell types
Tirosh Shapira et al.
Frontiers in microbiology, 11, 553962-553962 (2020-10-13)
A screen of a eukaryotic kinase inhibitor library in an established intracellular infection model identified a set of drug candidates enabling intracellular killing of Mycobacterium tuberculosis (M.tb). Screen validity was confirmed internally by a Z' = 0.5 and externally by
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0781-5MG | 04061832450834 |
| SML0781-25MG | 04061832450827 |