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Merck
CN

SML0795

PF-670462

≥98% (HPLC)

Synonym(s):

4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride, PF670462

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About This Item

Empirical Formula (Hill Notation):
C19H20FN5 · 2HCl
CAS Number:
950912-80-8
Molecular Weight:
410.32
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)c2nc[n](c2c4nc(ncc4)N)C3CCCCC3.Cl.Cl

InChI

1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H

InChI key

PSNKGVAXBSAHCH-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity).
PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I.
PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000181510
0000181510
0000063356
0000063357
0000127310

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Patton AP, et al.
The Journal of Neuroscience, 36(36), 9326-9341 (2016)
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Motor neuron disease (MND) is a progressive neurodegenerative disease with no effective treatment. One of the principal pathological hallmarks is the deposition of TAR DNA binding protein 43 (TDP-43) in cytoplasmic inclusions. TDP-43 aggregation occurs in both familial and sporadic

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