SML0859
WDR5-0103
≥98% (HPLC)
Synonym(s):
3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-benzoic acid methyl ester, Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
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About This Item
Empirical Formula (Hill Notation):
C21H25N3O4
CAS Number:
Molecular Weight:
383.44
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
WDR5-0103 is a WD40-repeat antagonist that binds to WDR55 central cavity. WDR5-0103 inhibits MLL1 histone methyltransferase activity in vitro through disruption of the interaction of MLL with WDR5.
WDR5-0103 is a WD40-repeat antagonist.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jimsheena V Karakkat et al.
Nucleic acids research, 47(19), 10086-10103 (2019-09-19)
The metabolic sensor Per-Arnt-Sim (Pas) domain-containing serine/threonine kinase (PASK) is expressed predominantly in the cytoplasm of different cell types, although a small percentage is also expressed in the nucleus. Herein, we show that the nuclear PASK associates with the mammalian
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