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Merck
CN

SML0890

Sigma-Aldrich

SB 452533

≥98% (HPLC)

Synonym(s):

N-(2-Bromophenyl)-N′-[2-[ethyl(3-methylphenyl)amino]ethyl]urea, SB-452533

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About This Item

Empirical Formula (Hill Notation):
C18H22BrN3O
CAS Number:
459429-39-1
Molecular Weight:
376.29
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)

InChI key

IFJYEGJUQIBBQV-UHFFFAOYSA-N

Biochem/physiol Actions

SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor with a pKb of 7.7 versus capsaicin and pIC50 of 7.0 versus pH. At higher concentrations, SB-452533 is also active at TRPM8 with an IC50 of 571 nM. It has a high clearance rate, so is not suitable for in vivo use.
SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H410

Precautionary Statements

P273 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
123M4601V

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