SML0905
Dimethylenastron
≥98% (HPLC)
Synonym(s):
2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
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About This Item
Empirical Formula (Hill Notation):
C16H18N2O2S
CAS Number:
Molecular Weight:
302.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21)
InChI key
RUOOPLOUUAYNPY-UHFFFAOYSA-N
Biochem/physiol Actions
Dimethylenastron is specific, reversible inhibitor of the mitotic motor kinesin Eg5.
Dimethylenastron is specific, reversible inhibitor of the mitotic motor kinesin Eg5. Dimethylenastron inhibits bipolar spindle formation, and inhibits proliferation, migration and invasion of several pancreatic cancer cell lines in cell based assays.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Don-Marc Franchini et al.
Cell reports, 26(1), 94-107 (2019-01-04)
Despite the clinical success of blocking inhibitory immune checkpoint receptors such as programmed cell death-1 (PD-1) in cancer, the mechanisms controlling the expression of these receptors have not been fully elucidated. Here, we identify a post-transcriptional mechanism regulating PD-1 expression
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0905-5MG | 04061833066690 |
| SML0905-25MG | 04061833066683 |