Skip to Content
Merck
CN

SML0907

Apoptolidin A Ready Made Solution

1 mg/mL in DMSO

Synonym(s):

Apoptolidin, FU 40A

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C58H96O21
CAS Number:
194874-06-1
Molecular Weight:
1129.37
PubChem Substance ID:
329825615
UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
200-664-3
Form:
DMSO solution
Quality level:
200

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

WILMROCKORZEMQ-XIQAQMKHSA-N

InChI

1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1

SMILES string

CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O

biological source

Amycolatopsis sp.

form

DMSO solution

concentration

1 mg/mL in DMSO

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

General description

Chemical structure: macrolide

Biochem/physiol Actions

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells.
Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F0F1-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E1A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
064M4113V
14140409
32140401
32140402

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Related Content

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service