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Merck
CN

SML0920

Sigma-Aldrich

α-Phenyl tropolone

≥98% (HPLC)

Synonym(s):

2-Hydroxy-3-phenyl-2,4,6-cycloheptatrien-1-one, 3-Phenyltropolone

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About This Item

Empirical Formula (Hill Notation):
C13H10O2
CAS Number:
341033-14-5
Molecular Weight:
198.22
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

, yellow to gray to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8 (Ki = 0.26 and 1.09 nM, respectively). The compound, α-Phenyl tropolone, does not affect other HDAC isoforms up to concentrations of 20 μM, with the exception of HDAC 6 (Ki = 527 nM).
α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
123M4613V

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S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat

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