SML0964
KNK437
≥98% (HPLC)
Synonym(s):
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
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About This Item
Empirical Formula (Hill Notation):
C13H11NO4
CAS Number:
Molecular Weight:
245.23
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O
InChI key
LZGGUFLRKIMBDQ-UHFFFAOYSA-N
InChI
1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Related Categories
Application
KNK437 has been used:
- as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
- as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
- as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release
Biochem/physiol Actions
KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.
KNK437 is a heat shock protein inhibitor.
KNK437 is a benzylidene lactam compound.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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S Yokota et al.
Cancer research, 60(11), 2942-2948 (2000-06-13)
Cells exposed to heat or other types of stressors transiently synthesize a group of proteins known as heat shock proteins (HSPs). A nonlethal heat treatment can elicit in the cells an ability to resist subsequent lethal heat treatments. We report
An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators
Marino L V, et al.
Nutrition, 32(3), 375-383 (2016)
Heat shock factor 1 epigenetically stimulates glutaminase-1-dependent mTOR activation to promote colorectal carcinogenesis
Li J, et al.
Molecular Therapy, 26(7), 1828-1839 (2018)
Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance
Xu J, et al.
Theranostics, 9(10), 2999-2999 (2019)
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