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SML0964

KNK437

≥98% (HPLC)

Synonym(s):

3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde

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About This Item

Empirical Formula (Hill Notation):
C13H11NO4
CAS Number:
218924-25-5
Molecular Weight:
245.23
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O

InChI

1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2

InChI key

LZGGUFLRKIMBDQ-UHFFFAOYSA-N

Application

KNK437 has been used:
  • as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
  • as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
  • as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.
KNK437 is a heat shock protein inhibitor.
KNK437 is a benzylidene lactam compound.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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