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Merck
CN

SML0967

Sigma-Aldrich

TAE-1

≥98% (HPLC)

Synonym(s):

2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide

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About This Item

Empirical Formula (Hill Notation):
C39H51N6O9 · 3I
CAS Number:
1414469-59-2
Molecular Weight:
1128.57
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 also inhibits cholinesterases AChE and BuChE.
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 is a sym-triazine with dual activity against Alzheimer′s disease. TAE-1 inhibits cholinesterases AChE and BuChE with IC50 values of 0.3 and 3.9 μM. Studies using TAE-1 on differentiated human SH-SY5Y neuronal cells have suggested that it can stimulate synapse formation and promote the differentiation of human neurons, increasing neurite extension.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
044M4773V

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