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Merck
CN

SML1013

PRT4165

≥98% (HPLC)

Synonym(s):

2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethylene)-1,3-indandione, NSC 600157

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About This Item

Empirical Formula (Hill Notation):
C15H9NO2
CAS Number:
31083-55-3
Molecular Weight:
235.24
NACRES:
NA.77
PubChem Substance ID:
329825631
UNSPSC Code:
12352200
MDL number:
MFCD00435709

Key Documents

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InChI

1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H

SMILES string

O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3

InChI key

OMHZFEWYVFWVLI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to gray

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.
PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000531743
0000531743
0000526450
0000526450
0000465755

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Dario Tommasini et al.
iScience, 26(4), 106358-106358 (2023-03-31)
Neurological disease is characterized the by dysfunction of specific neuroanatomical regions. To determine whether region-specific vulnerabilities have a transcriptional basis at cell-type-specific resolution, we analyzed gene expression in mouse oligodendrocytes across various brain regions. Oligodendrocyte transcriptomes cluster in an anatomical

Articles

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Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

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