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Merck
CN

SML1028

Sigma-Aldrich

MPT0B014

≥98% (HPLC)

Synonym(s):

6-Quinolinyl(3,4,5-trimethoxyphenyl)methanone, B014

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About This Item

Empirical Formula (Hill Notation):
C19H17NO4
CAS Number:
Molecular Weight:
323.34
UNSPSC Code:
12352200
NACRES:
NA.77
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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

MPT0B014 inhibits tubulin polymerization and disrupts microtubules in the cytoskeleton.
MPT0B014 inhibits tubulin polymerization and disrupts microtubules in the cytoskeleton. The compound MPT0B014 inhibits proliferation of the lung cancer cells A549, H1299, and H226 with IC50 values of 41, 46 and 42 nM, respectively. MPT0B014 induces cell cycle arrest and apoptosis, inhibits tumor growth in lung cancer xenografts, and potentiates inhibition of tumor growth by erlotinib.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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