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Merck
CN

SML1056

Sigma-Aldrich

CX4338

≥98% (HPLC)

Synonym(s):

4,4-Dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]-1-cyclohexene-1-carbothioamide

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About This Item

Empirical Formula (Hill Notation):
C22H24N2OS
CAS Number:
41609-06-7
Molecular Weight:
364.50
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C22H24N2OS/c1-22(2)13-18(23-15-16-9-5-3-6-10-16)20(19(25)14-22)21(26)24-17-11-7-4-8-12-17/h3-12,23H,13-15H2,1-2H3,(H,24,26)

InChI key

AESCWMGFNWXKFR-UHFFFAOYSA-N

Biochem/physiol Actions

CX4338 is a CXCR2 receptor antagonist.
CX4338 is a CXCR2 receptor antagonist. In cell based assays, CX4338 blocks CXCL8-induced receptor internalization and β-arrestin recruitment, but enhances G-protein-mediated signaling events such as calcium mobilization and ERK phosporylation. The comopund inhibits CXCL8-induced neutrophil chemotaxis, and LPS-induced PMN migration in a mouse airway inflammaiton model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
054M4610V

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