SML1056
CX4338
≥98% (HPLC)
Synonym(s):
4,4-Dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]-1-cyclohexene-1-carbothioamide
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About This Item
Empirical Formula (Hill Notation):
C22H24N2OS
CAS Number:
Molecular Weight:
364.50
UNSPSC Code:
51111800
NACRES:
NA.77
InChI
1S/C22H24N2OS/c1-22(2)13-18(23-15-16-9-5-3-6-10-16)20(19(25)14-22)21(26)24-17-11-7-4-8-12-17/h3-12,23H,13-15H2,1-2H3,(H,24,26)
InChI key
AESCWMGFNWXKFR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
CX4338 is a CXCR2 receptor antagonist.
CX4338 is a CXCR2 receptor antagonist. In cell based assays, CX4338 blocks CXCL8-induced receptor internalization and β-arrestin recruitment, but enhances G-protein-mediated signaling events such as calcium mobilization and ERK phosporylation. The comopund inhibits CXCL8-induced neutrophil chemotaxis, and LPS-induced PMN migration in a mouse airway inflammaiton model.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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