SML1115
CP466722
≥98% (HPLC)
Synonym(s):
1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-Triazol-5-amine
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About This Item
Empirical Formula (Hill Notation):
C17H15N7O2
CAS Number:
Molecular Weight:
349.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23)
SMILES string
NC1=NC(C2=CC=CC=N2)=NN1C3=NC=NC4=C3C=C(OC)C(OC)=C4
InChI key
ILBRKJBKDGCSCB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 0.5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase.
CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase. The compound CP466722 disrupts ATM-dependent checkpoint cell cylce events, and reverses ATM-dependent substrate phosphorylation and downstream signaling events following exposure to ionizing radiation.
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