SML1142
VU0071063
≥98% (HPLC)
Synonym(s):
7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
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About This Item
Empirical Formula (Hill Notation):
C18H22N4O2
CAS Number:
Molecular Weight:
326.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
VU0071063, ≥98% (HPLC)
InChI
1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
SMILES string
CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O
InChI key
ZFZAIHKQJBMYLO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.
VU0071063 is a specific activator of SUR1-containing KATP channels.
VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining β-cell physiology, KATP channel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Direct activation of beta-cell KATP channels with a novel xanthine derivative
Raphemot RS, et al.
Molecular Pharmacology, mol-114 (2014)
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