SML1158
(2S)-Hypusine dihydrochloride
≥95% (HPLC)
Synonym(s):
(+)-Hypusine dihydrochloride, N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H23N3O3 · 2HCl
Molecular Weight:
306.23
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
SMILES string
[H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
InChI
1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
InChI key
UTSZZUVUESAPQD-AHBBCRTASA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.
(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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