SML1176
Carboxypyridostatin trifluoroacetate salt
≥95% (HPLC)
Synonym(s):
4-[[[2,6-Bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-1H-1,2,3-triazole-1-propanoic acid trifluoroacetate salt, carboxyPDS trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C35H34N10O7 · xC2HF3O2
CAS Number:
Molecular Weight:
706.71 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
H2O: 25 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Carboxypyridostatin trifluoroacetate salt has been used in the study of translation, stimulated by DHX36 (DEAH-box helicase 36) binding at G-rich sites in mRNA untranslated regions.
Biochem/physiol Actions
Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures.
Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures. Immunofluorescent staining of carboxyPDS treated cells using an anti G-quadruplex antibody reveals staining only in the cytoplasm and not the nucleus, demonstrating selectivity against DNA G-quadruplex structures.
Other Notes
Light sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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DHX36 binding at G-rich sites in mRNA untranslated regions promotes translation.
Sauer M, et al.
bioRxiv (2017)
Pauline Herviou et al.
Nature communications, 11(1), 2661-2661 (2020-05-29)
RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo, indicating the existence of poorly characterized molecular machinery that remodels RG4s and maintains them unfolded.
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