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Merck
CN

SML1203

Sigma-Aldrich

2-PMAP

≥98% (HPLC)

Synonym(s):

(2-Pyridylmethyl)(2-hydroxyphenyl)amine, 2-N-(2-Pyridylmethyl)aminophenol, 2-[(2-Pyridinylmethyl)amino]-phenol; (2-Hydroxyphenyl)(2-pyridylmethyl)amine

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About This Item

Empirical Formula (Hill Notation):
C12H12N2O
CAS Number:
102212-26-0
Molecular Weight:
200.24
MDL number:
MFCD24550644
UNSPSC Code:
12352200
PubChem Substance ID:
329825716
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

, white to dark brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=CC=C1NCC2=NC=CC=C2

InChI

1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2

InChI key

GXJRVWZNMZGWAQ-UHFFFAOYSA-N

Biochem/physiol Actions

2-PMAP is a brain penetrant inhibitor of amyloid precursor protein (APP) production.
2-PMAP is a brain penetrant inhibitor of amyloid precursor protein (APP) production. 2-PMAP lowers levels of the amyloid precursor protein (APP) in CHO APP751SW cells. Also it reduces brain level of APP in mice model. 2-PMAP exhibits no cellular toxicity up to 100 μM.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
015M4725V

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