SML1215
Cuspin-1
≥98% (HPLC)
Synonym(s):
(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
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About This Item
Empirical Formula (Hill Notation):
C13H10BrNO
CAS Number:
Molecular Weight:
276.13
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
SMILES string
CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
InChI key
AJZRSLVRFSCCIL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.
Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN).
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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