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SML1238

Ertapenem sodium

Name: Ertapenem sodium
Brand: SIGMA

≥90% (HPLC), powder, carbopenem antibiotic

Synonym(s):

(4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium, ZD-443 sodium

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₄N₃O₇S · Na

CAS Number:

153773-82-1

Molecular Weight:

497.50

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥90% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

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Product Name

Ertapenem sodium, ≥90% (HPLC)

Quality Level

100

assay

≥90% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to yellow

storage temp.

room temp

SMILES string

[Na+].S([C@@H]3CN[C@@H](C3)C(=O)Nc4cc(ccc4)C(=O)[O-])C1=C(N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C)C(=O)O

InChI

1S/C22H25N3O7S.Na/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30;/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32);/q;+1/p-1/t9-,10-,13+,14+,15-,16-;/m1./s1

InChI key

ZXNAQFZBWUNWJM-HRXMHBOMSA-M

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Ertapenem sodium has been used as a carbapenem in the NitroSpeed-Carba NP test in minimum inhibitory concentration (MIC) testing for differentiation of carbapenemases in Enterobacterales and Pseudomonas aeruginosa. It has also been used as an antibiotic to study its effects on the survival of septic mice.

Biochem/physiol Actions

Broad spectrum carbopenem antibiotic

Ertapenem is a broad spectrum carbopenem antibiotic. Ertapenem is active against both gram-positive and gram-negative bacteria. Ertapenem shows an extended duration of action in vivo due to its reversible binding to serum protein.

Ertapenem sodium exhibits its activity against several aerobic and anaerobic microorganisms and is more resistant to β-lactamase enzymes. It has been studied in the treatment of several infectious diseases.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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The Effect of Radiation Dose and Variation in Neupogen® Initiation Schedule on the Mitigation of Myelosuppression during the Concomitant GI-ARS and H-ARS in a Nonhuman Primate Model of High-dose Exposure with Marrow Sparing.

Thomas J MacVittie et al.

Health physics, 109(5), 427-439 (2015-10-02)

A nonhuman primate (NHP) model of acute high-dose, partial-body irradiation with 5% bone marrow (PBI/BM5) sparing was used to assess the effect of Neupogen® [granulocyte colony stimulating factor (G-CSF)] to mitigate the associated myelosuppression when administered at an increasing interval

A Critical Review of Analytical Methods for Determination of Ertapenem Sodium.

Tahisa Marcela Pedroso et al.

Critical reviews in analytical chemistry, 46(1), 15-21 (2016-02-10)

Antimicrobials have unquestionable importance in the control of many diseases; however the constant concern with evolution of resistant microorganisms is increasing. Ertapenem sodium is a β-lactam antibiotic of the carbapenem class that has a broader activity spectrum than most other

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.

Daniele C Nascimento et al.

Nature communications, 8, 14919-14919 (2017-04-05)

Patients who survive sepsis can develop long-term immune dysfunction, with expansion of the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients is not clear. Here we show that IL-33 has a major function in the

RP-HPLC×HILIC chromatography for quantifying ertapenem sodium with a look at green chemistry.

Tahisa M Pedroso et al.

Talanta, 160, 745-753 (2016-09-04)

Ertapenem sodium is a polar and ionizable compound; therefore, it has little retention on traditional C18 columns in reverse-phase high-performance liquid chromatography, even using a highly-aqueous mobile phase that can result in dewetting in the stationary phase. Thus, the most

The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.

Fernanda V E Silva Castanheira et al.

Shock (Augusta, Ga.), 49(6), 682-689 (2018-03-29)

Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection, and chemokines play a key role in recruiting neutrophils. However, in sepsis chemokines could also contribute

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Global Trade Item Number

SKU	GTIN
SML1238-50MG	04061837107771
SML1238-10MG	04061837107764

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