SML1273
ML347
≥98% (HPLC)
Synonym(s):
5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, LDN-193719, VU0469381
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About This Item
Empirical Formula (Hill Notation):
C22H16N4O
CAS Number:
Molecular Weight:
352.39
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3
SMILES string
COC(C=C1)=CC=C1C2=CN3N=CC(C4=CC=CC5=C4C=CC=N5)=C3N=C2
InChI key
FVRYPYDPKSZGNS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
ML347 is a derivative of dorsomorphin that is a highly selective antagonist of BMP receptor isotypes ALK1 and ALK2 (IC50 values = 46 and 32 nM, respectively). ML347 has little effect on other ALK isoforms, including ALK3 (IC50 = 10 μM).
ML347 is a highly selective antagonist of BMP receptor isotypes ALK1 and ALK2.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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