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Merck
CN

SML1281

Sigma-Aldrich

Capecitabine Ready Made Solution

10 mg/mL in DMSO

Synonym(s):

5′-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

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About This Item

Empirical Formula (Hill Notation):
C15H22FN3O6
CAS Number:
154361-50-9
Molecular Weight:
359.35
UNSPSC Code:
41116107

Key Documents

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form

DMSO solution

Quality Level

200

concentration

10 mg/mL in DMSO

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1

InChI key

GAGWJHPBXLXJQN-UORFTKCHSA-N

Biochem/physiol Actions

Capecitabine is a fluoropyrimidine carbamate that undergoes preferential conversion to 5-fluorouracil in cancerous tissues.
Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site.
Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5′-Deoxy-5-fluorocytidine (5′-DFCR) and 5′-Deoxy-5-fluorouridine (5′-DFUR), to form 5-fluorouracil.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350,H360FD

Hazard Classifications

Carc. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086M4070V
11160211

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J Schüller et al.
Cancer chemotherapy and pharmacology, 45(4), 291-297 (2001-02-07)
[corrected] Capecitabine (Xeloda) is a novel fluoropyrimidine carbamate rationally designed to generate 5-fluorouracil (5-FU) preferentially in tumors. The purpose of this study was to demonstrate the preferential activation of capecitabine, after oral administration, in tumor in colorectal cancer patients, by

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