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SML1285

Febuxostat

98.5-102.0% (dry basis), powder, xanthine oxidase inhibitor

Synonym(s):

2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid, Adenuric, Atenuri, Uloric

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About This Item

Empirical Formula (Hill Notation):
C16H16N2O3S
CAS Number:
144060-53-7
Molecular Weight:
316.37
UNSPSC Code:
51111800
PubChem Substance ID:
329825764
NACRES:
NA.77
MDL number:
MFCD00871598
Assay:
98.5-102.0%
Form:
powder
Quality level:
200
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Product Name

Febuxostat, 98.5-102.0%

Quality Level

200

assay

98.5-102.0%

form

powder

storage temp.

2-8°C

SMILES string

CC(C)COC1=C(C#N)C=C(C2=NC(C)=C(C(O)=O)S2)C=C1

InChI

1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)

InChI key

BQSJTQLCZDPROO-UHFFFAOYSA-N

General description

Febuxostat is a potent, non-purine compound, which inhibits the expression of cytokines/chemokines. It has also been reported to inhibit LPS-induced TNF-α, VCAM-1, MMP9 and MCP-1 expression.

Biochem/physiol Actions

Febuxostat is a potent non-purine xanithine oxidase inhibitor.
Febuxostat is a potent non-purine xanithine oxidase inhibitor. Febuxostat is used in urate lowering therapies (ULTs) for the treatment of gout.

Disclaimer

Freely soluble in N,N-dimethyl formamide, Soluble in dimethyl sulfoxide, sparingly soluble in ethanol or trichloromethane, slightly soluble in methanol, practically insoluble in water

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000508188
0000508188
0000369121
0000316474
0000316474

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Johji Nomura et al.
PloS one, 8(9), e75527-e75527 (2013-10-03)
Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular
Yoshiro Tanaka et al.
Free radical biology & medicine, 162, 298-308 (2021-01-21)
Accumulating evidence suggests that high serum uric acid (UA) is associated with left ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory mechanism of the terminal step in ATP and purine degradation, the pathophysiological role of cardiac

Global Trade Item Number

SKUGTIN
SML1285-1G04061838356949