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Merck
CN

SML1328

AZ20

≥98% (HPLC)

Synonym(s):

4{4-[(3R)3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}1Hindole

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About This Item

Empirical Formula (Hill Notation):
C21H24N4O3S
CAS Number:
1233339-22-4
Molecular Weight:
412.51
NACRES:
NA.77
PubChem Substance ID:
329825787
UNSPSC Code:
12352200
MDL number:
MFCD25976730

Key Documents

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InChI

1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1

SMILES string

CS(C1(CC1)C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)(=O)=O

InChI key

SCGCBAAYLFTIJU-CQSZACIVSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

AZ20 is cell penetrant potent and selective ATR (ataxia telangiectasia and Rad3-related protein) kinase inhibitor that potently inhibits the growth of LoVo colorectal adenocarcinoma xenografts in mice.
AZ20 is cell penetrant potent and selective ATR kinase inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000057417
017M4617V
065M4610V

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Ilaria Stadiotti et al.
Frontiers in cardiovascular medicine, 9, 878268-878268 (2022-07-12)
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome characterized by impaired left ventricular (LV) diastolic function, with normal LV ejection fraction. Aortic valve stenosis can cause an HFpEF-like syndrome by inducing sustained pressure overload (PO) and cardiac
Madeeha Ghazi et al.
Nucleic acids research, 51(19), 10451-10466 (2023-09-12)
Melanin protects skin cells from ultraviolet radiation-induced DNA damage. However, intermediates of eumelanin are highly reactive quinones that are potentially genotoxic. In this study, we systematically investigate the effect of sustained elevation of melanogenesis and map the consequent cellular repair
Hironori Abe et al.
Nature communications, 13(1), 7212-7212 (2022-11-29)
Meiotic sex chromosome inactivation (MSCI) is an essential process in the male germline. While genetic experiments have established that the DNA damage response (DDR) pathway directs MSCI, due to limitations to the experimental systems available, mechanisms underlying MSCI remain largely

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