SML1376
BTC
≥95% (HPLC)
Synonym(s):
2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol, 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
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About This Item
Empirical Formula (Hill Notation):
C14H10O2S
CAS Number:
Molecular Weight:
242.29
UNSPSC Code:
51111800
NACRES:
NA.77
InChI
1S/C14H10O2S/c15-11-4-1-9(2-5-11)13-7-10-3-6-12(16)8-14(10)17-13/h1-8,15-16H
InChI key
MDGWZLQPNOETLH-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
protect from light
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM).
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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