SML1440
Bithionol
98% (HPLC)
Synonym(s):
2,2′-Thio-bis(4,6-dichlorophenol), Bis(2-hydroxy-3,5-dichlorophenyl) sulfide
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About This Item
Empirical Formula (Hill Notation):
C12H6Cl4O2S
CAS Number:
Molecular Weight:
356.05
EC Number:
202-565-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2003535
MDL number:
Assay:
98% (HPLC)
Form:
powder
assay
98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
Oc1c(Cl)cc(Cl)cc1Sc2cc(Cl)cc(Cl)c2O
InChI
1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
InChI key
JFIOVJDNOJYLKP-UHFFFAOYSA-N
Biochem/physiol Actions
Bithionol was originally used as an anthelmintic. Bithionol has more recently been investigated for potential use as an anti-ovarian cancer drug and as a possible treatment for Alzheimer′s disease. Bithionol inhibited Aβ42 seeding capacity and fibril growth, stabilized diffuse amyloid plaques, reduced the levels of Aβ42 oligomers and ameliorated synapse loss, neuronal damage and astrogliosis in a transgenic mouse model of Alzheimer′s disease. Bithionol appears to act through several mechanisms of action including uncoupling of oxidative phosphorylation, ROS generation, NF-κB inhibition, autotaxin inhibition, and as an activator of Slack sodium-activated potassium (KNa) channels.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Vijayalakshmi N Ayyagari et al.
BMC cancer, 14, 61-61 (2014-02-06)
Drug resistance is a cause of ovarian cancer recurrence and low overall survival rates. There is a need for more effective treatment approaches because the development of new drug is expensive and time consuming. Alternatively, the concept of 'drug repurposing'
Simona Eleuteri et al.
Neurobiology of disease, 74, 144-157 (2014-09-01)
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this process represents an effective
Leonard K Kaczmarek
ISRN neuroscience, 2013(2013) (2013-12-10)
The
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1440-50MG | 04061832637556 |