SML1466
ABH hydrochloride
≥98% (HPLC), arginase inhibitor, powder
Synonym(s):
2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H14BNO4 · HCl
CAS Number:
Molecular Weight:
211.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
ABH hydrochloride, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +8 to +13°, c = 0.7 in H2O
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
InChI
1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
InChI key
XCUVEZUCSHVMRK-JEDNCBNOSA-N
Biochem/physiol Actions
Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.
ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.
ABH is a highly potent and specific arginase inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Structure and function of arginases.
Ash D E.
The Journal of Nutrition, 134(10), 2760S-2764S (2004)
Chronic oral administration of the arginase inhibitor 2 (S)?amino?6?boronohexanoic acid (ABH) improves erectile function in aged rats.
Segal R, et al.
Journal of Andrology, 33(6), 1169-1175 (2012)
Yvonne Grobben et al.
Journal of structural biology: X, 4, 100014-100014 (2020-07-11)
Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized the potencies of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1466-25MG | 04061833226193 |
| SML1466-5MG | 04061833226209 |