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Merck
CN

SML1537

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

Synonym(s):

3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione, 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran, Cantharidine, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

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About This Item

Empirical Formula (Hill Notation):
C10H12O4
CAS Number:
56-25-7
Molecular Weight:
196.20
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Form:
solution
Quality level:
200

Key Documents

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Product Name

Cantharidin Ready Made Solution, 0.1 mg/mL in DMSO

SMILES string

O1[C@@H]2[C@]3([C@@]([C@H]1CC2)(C(=O)OC3=O)C)C

InChI key

DHZBEENLJMYSHQ-XCVPVQRUSA-N

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

biological source

insect

form

solution

concentration

0.1 mg/mL in DMSO

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Related Categories

Other Notes

Stable for at least two years at 2-8° C.

Biochem/physiol Actions

Cantharidin inhibits protein phosphatase 2A.
It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity. In addition, cantharidin can work against multidrug-resistant cells. In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis. PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F

flash_point_c

87 °C

Regulatory Information

高风险级别生物产品--毒素类产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000214291
0000214291
0000184050
0000184050
0000085376

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Wei Li et al.
Cancer science, 101(5), 1226-1233 (2010-03-25)
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in control of cell cycle, apoptosis, and cell-fate determination. Owing to its
L Moed et al.
Archives of dermatology, 137(10), 1357-1360 (2001-10-27)
Cantharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug
Rolf Rauh et al.
Chinese medicine, 2, 8-8 (2007-07-06)
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the

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