SML1566
Leucinostatin A+B mixture
≥95% (mixture of Leucinostatin A+B, HPLC), (Paecilomyces lilacinus)
Synonym(s):
Antibiotic 1907-II, Antibiotic 1907-VIII, Leucinostatin A+B
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About This Item
NACRES:
NA.77
UNSPSC Code:
51111800
Quality Level
biological source
(Paecilomyces lilacinus)
assay
≥95% (mixture of Leucinostatin A+B, HPLC)
form
powder
solubility
DMF: 10 mg/mL, DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus.
Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus. Leucinostatins display broad bio-activity against gram-positive bacteria, fungi, plants and tumor cell lines. They play a role as uncouplers in the inner mitochondria membrane and inhibit mitochondrial ATP synthesis. Recently, interest in Leucinostatins has focused on other aspects such as understanding their activity: insulin-like growth factor I regulators, ionophore, inhibitors of cell surface expression of viral glycoproteins and their potent in vitro and in vivo anti-trypanosomal activity.
Preparation Note
Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13).
Other Notes
Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13).
Stable at −20 °C for at least 2 years.
Analyte
Description
Leuconostatin A
Leucinostatin B
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Qingkang Lyu et al.
Cell stress & chaperones, 25(2), 235-243 (2020-01-16)
Dysregulation of retinal pigment epithelium (RPE) cells is the main cause of a variety of ocular diseases. Potentially heat shock proteins, by preventing molecular and cellular damage and modulating inflammatory disease, may exert a protective role in eye disease. In
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1566-1MG | 04061826704004 |
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