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Merck
CN

SML1580

NSC156529

≥98% (HPLC)

Synonym(s):

6-Methyl-2-phenyl-10-(phenylthio)-1,2-dihydro-24-anthra[1,9-bc]thiophene chloride, 6-Methyl-2-phenyl-10-(phenylthio)-1H-anthra[1,9-bc]thiophenium chloride, CID 3246498, NSC 156529, NSC-156529

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About This Item

Empirical Formula (Hill Notation):
C28H21ClS2
CAS Number:
41134-88-7
Molecular Weight:
457.05
UNSPSC Code:
12352202
NACRES:
NA.77

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InChI

1S/C28H21S2.ClH/c1-19-22-14-8-16-25(29-20-10-4-2-5-11-20)27(22)24-18-30(21-12-6-3-7-13-21)26-17-9-15-23(19)28(24)26;/h2-17H,18H2,1H3;1H/q+1;/p-1

InChI key

KLQVNXJBZZWIIV-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

NSC156529 is a potent inhibitor of Akt/PKB pathway that decreases the proliferation of human cancer cells in vitro, and inhibits tumor growth in a prostate tumor xenograft model. NSC156529 inhibits interaction of PDPK1 and AKT1 by direct binding to PDPK1. NSC156529 increases the differentiation status of cancer cells.
Potent inhibitor of Akt/PKB pathway

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
046M4606V

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