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Merck
CN

SML1676

Sigma-Aldrich

R9-caPep trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

D-Arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-L-cysteinyl-L-cysteinyl-L-leucylglycyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosine, H-RDRDRDRDRDRDRDRDRD-CC-LGIPEQEY-OH

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About This Item

Empirical Formula (Hill Notation):
C103H183N47O26S2 · xC2HF3O2
Molecular Weight:
2559.98 (free base basis)
UNSPSC Code:
12352202

Key Documents

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Assay

≥95% (HPLC)

form

powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains.
R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains. R9-caPep selectively kills human neuroblastoma cells (IC50 = 10 - 32 μM vs. IC50 = 98 μM/PBMCs and >100 μM/neural crest stem cells), especially those with MYCN gene amplification, by interfering with PCNA-dependent replication fork extension and DSB HR repair, resulting in exacerbated replication stress. R9-caPep intratumoral injection (3 times a week) is reported to suppress SK-N-BE(2)c xenograft tumor expansion in mice in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086M4739V

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