SML1676
R9-caPep trifluoroacetate salt
≥95% (HPLC)
Synonym(s):
D-Arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-L-cysteinyl-L-cysteinyl-L-leucylglycyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosine, H-RDRDRDRDRDRDRDRDRD-CC-LGIPEQEY-OH
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About This Item
Empirical Formula (Hill Notation):
C103H183N47O26S2 · xC2HF3O2
Molecular Weight:
2559.98 (free base basis)
UNSPSC Code:
12352202
assay
≥95% (HPLC)
form
powder
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains.
R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains. R9-caPep selectively kills human neuroblastoma cells (IC50 = 10 - 32 μM vs. IC50 = 98 μM/PBMCs and >100 μM/neural crest stem cells), especially those with MYCN gene amplification, by interfering with PCNA-dependent replication fork extension and DSB HR repair, resulting in exacerbated replication stress. R9-caPep intratumoral injection (3 times a week) is reported to suppress SK-N-BE(2)c xenograft tumor expansion in mice in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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