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SML1702

SW203668 trifluoroacetate

≥98% (HPLC)

Synonym(s):

4-(Amino(phenyl)methyl)-N-(6-methoxybenzo[d]thiazol-2-yl)benzamide trifluoroacetate, 4-(Aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C22H19N3O2S · CF3CO2H
CAS Number:
1673556-40-5
Molecular Weight:
503.49
UNSPSC Code:
12352200
PubChem Substance ID:
329826027
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(C(O)=O)F.NC(C1=CC=CC=C1)C(C=C2)=CC=C2C(NC3=NC4=CC=C(OC)C=C4S3)=O

InChI

1S/C22H19N3O2S.C2HF3O2/c1-27-17-11-12-18-19(13-17)28-22(24-18)25-21(26)16-9-7-15(8-10-16)20(23)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-13,20H,23H2,1H3,(H,24,25,26);(H,6,7)

InChI key

SIUPHFAIFLEFIT-UHFFFAOYSA-N

Biochem/physiol Actions

SW203668 is activated in cell lines expressing cytochrome P450 (CYP) 4F11 to an irreversible inhibitor of stearoyl CoA desaturase.
SW203668 is activated in cell lines expressing cytochrome P450 (CYP) 4F11 to an irreversible inhibitor of stearoyl CoA desaturase. Stearoyl CoA desaturase is not essential in the liver where SW203668 activation takes place, but is necessary for many tumor cells, several of which also express high levels of CYP4F11. SW203668 inhibited growth of lung carcinoma cell line H2122 with IC50 values of 0.029 μM and 0.007 μM, respectively for the (+) and (-) enantiomers. SW203668 also substantially reduced growth rate in H2122-derived tumors in immunodeficient mice.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000074156
0000047795
086M4613V

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Global Trade Item Number

SKUGTIN
SML1702-25MG04061832274294
SML1702-5MG04061832274300