SML1730
LP117
≥98% (HPLC)
Synonym(s):
2-[[4-Chloro-6-(6-quinolinylamino)-2-pyrimidinyl]thio]-hexanoic acid ethyl ester, Ethyl 2-((4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl)thio)hexanoate
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About This Item
Empirical Formula (Hill Notation):
C21H23ClN4O2S
CAS Number:
Molecular Weight:
430.95
UNSPSC Code:
12352202
SMILES string
ClC1=NC(SC(C(OCC)=O)CCCC)=NC(NC2=CC3=C(C=C2)N=CC=C3)=C1
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
LP117 is a pirinixic acid derivative that inhibits ABCB1-mediated drug transport and resistance in cancer cultures.
LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. LP117 effectively reduces drug-resistance in ABCB1-expressing neuroblastoma cultures while exhibiting no efficacy toward non-ABCB1 substrate cisplatin or in non-ABCB1-expressing cancer cultures.
hcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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