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Merck
CN

SML1730

Sigma-Aldrich

LP117

≥98% (HPLC)

Synonym(s):

2-[[4-Chloro-6-(6-quinolinylamino)-2-pyrimidinyl]thio]-hexanoic acid ethyl ester, Ethyl 2-((4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl)thio)hexanoate

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About This Item

Empirical Formula (Hill Notation):
C21H23ClN4O2S
CAS Number:
1056468-55-3
Molecular Weight:
430.95
UNSPSC Code:
12352202

Key Documents

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Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=NC(SC(C(OCC)=O)CCCC)=NC(NC2=CC3=C(C=C2)N=CC=C3)=C1

Biochem/physiol Actions

LP117 is a pirinixic acid derivative that inhibits ABCB1-mediated drug transport and resistance in cancer cultures.
LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. LP117 effectively reduces drug-resistance in ABCB1-expressing neuroblastoma cultures while exhibiting no efficacy toward non-ABCB1 substrate cisplatin or in non-ABCB1-expressing cancer cultures.

Hazard Statements

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
106M4736V

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