SML1755
ML264
≥98% (HPLC)
Synonym(s):
(2E)-3-(3-Chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-2-propenamide, CID 51003603, SID 117686865, SR03000002171
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About This Item
Empirical Formula (Hill Notation):
C17H21ClN2O4S
CAS Number:
Molecular Weight:
384.88
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
O=C(NCC(N(C)C1CCS(CC1)(=O)=O)=O)/C=C/C2=CC=CC(Cl)=C2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mL/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ML264 is a potent and selective inhibitor of Kruppel-like factor 5 (KLF5) expression. ML264 potently inhibits proliferation of colorectal cancer cells in vitro through modifications of the cell-cycle profile.
Potent and selective inhibitor of Kruppel-like factor 5 (KLF5) expression
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ainara Ruiz de Sabando et al.
Molecular cancer therapeutics, 15(1), 72-83 (2015-12-02)
Colorectal cancer is one of the leading causes of cancer mortality in Western civilization. Studies have shown that colorectal cancer arises as a consequence of the modification of genes that regulate important cellular functions. Deregulation of the WNT and RAS/MAPK/PI3K
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